Butein cell cycle

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August undefined, 2024

Webassays revealed butein directly interacted with Aurora B and inhibited its kinase activity. Along with the decrease of Aurora B and histone H3 phosphorylation, HCC cells were induced G2/M cell cycle arrest and subjected to cell apoptosis. Butein-mediated antitumor activities were substantially WebSurvivin plays a crucial role in G2/M cell cycle transition and apoptosis inhibition8 ... ˜e cells were treated with Butein, and the whole-cell extract (WCE) was prepared using the commercial ...

Effect of butein on the cell cycle of chronic myeloid …

WebNext, whether butein affected the cell cycle of CML cells was assessed, since an abnormal cell cycle is tightly associated with cell death. Butein arrested the KBM5 cells in S-phase of the cell ... WebButein is a chalcone of the chalconoids. It can be found in Toxicodendron vernicifluum (or formerly Rhus verniciflua ), Dahlia , Butea ( Butea monosperma ) and Coreopsis [1] It … bun and bowl santry

Butein: From ancient traditional remedy to modern …

WebButein is a chalcone derivative that can be isolated from various plants, including Rhus verniciflua Stokes, Semecarpus anacardium, and Dalbergia odorifera. ... obtusa, Thuja plicata, and Thujopsis dolabrata var. hondai. Yang et al. showed that hinokitiol exposure resulted in cell cycle arrest at the S phase and DNA damage response in both the ... WebDec 10, 2015 · Additionally, butein mediated cell cycle arrest in S-phase. Therefore, the butein-activated p53 pathway may arrest cells at S-phase, resulting in apoptotic cell death. The present study further demonstrated that butein reduced the protein expression of MDM2 in both p53-expressing KBM5 and p53-null K562 cells, while butein increased the … WebNov 27, 2024 · Butein (3,4,2′,4′-tetrahydroxychalcone) inhibited inhibitor of nuclear factor kappa-B kinase subunit beta ... and 2′-hydroxy-2,4,6-trimethoxy-5′,6′-naphthochalcone induced G2/M cell cycle arrest and apoptosis . An anticancer effect was common among these chalcones. The α,β-unsaturated carbonyl group in chalcones acted as a Michael ... half goblin half human dnd

Effects of butein on human osteosarcoma cell …

Butein ≥99%(HPLC) Selleck EGFR inhibitor

Webof HTLV-1-infected T-cell lines. T cells cultured with butein showed obvious apoptosis morphology, and cleavage of poly(ADP-ribose) polymerase with activation of caspase-3, -8 and -9. Pretreatment of cells with caspase inhibitor partially blocked butein-induced inhibition of cell viability. Butein also resulted in cell cycle arrest at G 1 phase. WebFurther experiments revealed butein exposure resulted in a cell cycle arrest at S and G2/M phase in U-2 OS cells. Importantly, this study found that butein activated the tumor suppressor p53, and trigged a p53-dependent senescence in U-2 OS cells. Knockdown of p53 suppressed the senescence and rescued the viability in butein-treated U-2 OS cells. half goat half woman tattooWebButein displays an anti-cancer effect by stimulating an anti-proliferative effect via, for example, inducing cell cycle arrest at the G2/M phase or by stimulating a pro-apoptotic effect via activation of mitochondria-dependent caspase-3 [41,42]. half goat one third cow

"WebMar 23, 2024 · Butein Induced Ovarian Cancer Cell Cycle Arrest and Cell Apoptosis. Cell cycle progression was monitored using flow cytometry. Exposure to butein resulted in … " - Butein cell cycle

Butein cell cycle

Butein inhibits cell proliferation and induces cell cycle arrest in

WebDec 1, 2024 · Butein leads to the production of ROS and induces cell cycle arrest [55], which leads to the activation of redox-signaling pathways, cell cycle arrest, cell function loss, oxidative stress, and ultimately cell death [61]. Further, the caspase-3 is activated, and the expression of Bax and Bcl-2 proteins changes which induces apoptosis [16]. Web4、tin.2 2) FoxO3a and its downstream molecules play a role in the synergistic effects of butein and cisplatin.23) Butein suppresses cell proliferation and enhances apoptosis in …

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WebMar 23, 2024 · Butein suppressed downstream signal transduction through higher binding affinity to IL-6. In ovarian cancer, butein inhibited cell proliferation, migration, and … WebIn summary, we revealed a novel mechanism by which butein induced cell cycle arrest and apoptosis in HCC cells. For the first time, Aurora B was validated to be the direct target of butein. By suppressing Aurora B, butein had substantial antitumor activities against HCC in vitro and in vivo. Supplementary Material. Supplementary figures and table.

Webbutene, also called Butylene, any of four isomeric compounds belonging to the series of olefinic hydrocarbons. The chemical formula is C4H8. The isomeric forms are 1-butene, … WebButein. Butein (20, 40, 3, 4-tetrahydroxychalcone), is a chalcone that has exhibited a wide range of pharmacological effects such as antiinflammatory, anticancer, antioxidant, and …

WebCell Cycle Volume 11, 2012 - Issue 1. Submit an article Journal homepage. Free access. 426 Views 23 CrossRef citations to date 0. Altmetric ... Chemoresistance is a major feature of MPM. Thus, this paper explores the effect of butein (3,4,2',4'-tetrahydroxychalcone), a naturally occurring NFκB and STAT3 inhibitor, on the tumorigenic properties ... Web(B) The clonogenicity of A549 and PC-9 cells after butein treatment. the results are expressed as mean ± SEM, n=6. a P < 0.05 versus control group, b P < 0.05 versus 5 μM butein group, c P < 0. ...

WebButein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4. Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells. Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a. Butein is a SIRT1 activator (STAC). - Mechanism of …

WebApr 5, 2016 · In this study, we investigated the anti-leukemic activity of butein and its action mechanisms in ALL. Butein was found to significantly suppress the cellular proliferation … bun and bowl dublinWebMar 23, 2024 · In ovarian cancer, butein inhibited cell proliferation, migration, and invasion, and induced cell cycle arrest and apoptosis. In addition, it decreased the growth of ovarian cancer cells in xenograft tumor models. Butein inhibited STAT3 phosphorylation and induced FoxO3a accumulation in the nucleus by inhibiting IL-6 signaling. half goat half personWebCell Research: Cell lines: Human hepatoma cells HepG2 Concentrations: ~50 μM Incubation Time: 1 days Method: The cells (5× 10 3 /mL) are incubated in triplicate in a 96-well plate in the presence or absence of indicated concentration of Butein in a final volume of 0.2 mL for different time intervals at 37 ℃. Thereafter, 20 μL MTT solution (5 mg/mL in … half globe wall lightWebFeb 7, 2024 · The role of butein in cell cycle distribution was analyzed using the propidium iodide (PI)/RNase staining buffer. Briefly, the cells were incubated in 6-well plates and treated with butein or DMSO for 24 h. Then, the cells were harvested, washed twice with ice-cold PBS, and fixed overnight with precooled 75% ethanol at 4°C. half gold half silver necklaceWebFurther experiments revealed butein exposure resulted in a cell cycle arrest at S and G2/M phase in U-2 OS cells. Importantly, this study found that butein activated the tumor … bun and braidsWebFigure 4: Butein induced cell cycle arrest and inhibited the activation of CDK2-Cyclin E complex in RS4-11 and MOLT-4 cells. A. Cells were treated with 0, 50 or 100 μM butein … half goblinsWebAug 18, 2024 · In lung cancer cells, butein promotes apoptosis and represses the expression of cyclooxygenase-2 ( 24 ). It is reported that butein triggers the suppression … bun and breakfast