Splet1 Register 2 Choose Submission Type 3 Submit Dataset 4 Accessing Private data 5 Post-submission DOWNLOAD SUBMISSION TOOL Tools Submission Tool PRIDE Submission Tool enables direct user submissions of protein and peptide identification or quantification data, along with the spectra to PRIDE Archive. More PRIDE Archive API Splet05. mar. 2024 · Thermal proteome profiling (TPP) identified the protein targets of XL888 in a pair of sensitive and unresponsive cell lines. Unbiased proteomics and phosphoproteomics analyses identified CDK2 as a driver of resistance to both BRAF and Hsp90 inhibitors and its expression is regulated by the transcription factor MITF upon …
Trans-Proteomic Pipeline - Wikipedia
SpletDownload Latest Version TPP_Setup_6.2.0.exe (223.2 MB) Get Updates Home Other Useful Business Software PRTG Network Monitor Making the lives of sysadmins easier Stay … Splet02. nov. 2015 · This approach, termed thermal proteome profiling (TPP), was used to identify drug targets and off-targets potentially responsible for side effects and to … foundations for health nc
Thermal proteome profiling: unbiased assessment of protein state …
SpletNational Center for Biotechnology Information Spletother proteins, or upon post-translational modifications. TPP uses multiplexed quantitative mass spectrometry-based proteomics to monitor the melting profile of thousands of expressed proteins. Importantly, this approach can be performed in vitro, in situ,or in vivo. It has been successfully applied to identify targets and off- Splet24. jun. 2024 · Thermal proteome profiling (TPP) allows for an unbiased search of drug targets and can be applied in living cells without requiring compound labeling. TPP is … disadvantages of business process improvement